Our Publications
A track record of interdisciplinary innovation in molecular imaging and drug discovery.
76
Publications
6.1k+
Citations
34
H-index
75%
Corresponding Author
2026
H-Aggregated Squaraine Probe NIR-II/MRI Double ReversalImaging for Liver Cancer Precise Surgical Navigation
Ruihu Song#, Yu Zhang #,Zewei Zhang ,Yanlin Wang, Xinning Sun, Lingling Liu, Xinxing Li, De-an Guo*, Hao Chen*
Sphingosine-1-Phosphate Receptor 3 Confers TumorMetastasis in Lung Cancer Resistant to Third-Generation EGFRInhibitor
Mengzhen Lai ,Jiaying Chen, Ye Qin, Hui Zhang, Zilu Pan ,Tao Zhang, Linjiang Tong, Haotian Tang,Gang Bai, Qiupei Liu, Yan Li,Fang Feng, Peiran Song, Yingqiang Liu, Yi Chen, Yan Fang, Bencan Tang,Meiyu Geng, Ker Yu*,Hao Chen*,Jian Ding*, Hua Xie*
Advances in near-infrared fluorescenceimaging for biomedicine
Huijie Wu# , Xinxing Li# , Zeyu Liu , Fan Song , Ruxin Cai , Hao Chen*，GuangleiZhang*
Tuning Photophysical Conflict Into Synergy:Stereoelectronic Planarity Disruption Unlocks ConcurrentAggregation-Enhanced ROS and NIR-II Fluorescence
Jie Liu*, Dalong Ma, Wen Li, Xunwen Zhang, Jiangwei Cui, Mengjie Zhang, Longling Wang, Ye Qin*, Hao Chen
1,3-and 1,4-linked polysaccharides uptake in intestinal cells relies on clathrin/dynamin 1/Rab5-dependent endocytosis.
Wenfeng Liao, Dianxiu Cao, Ying Wang, Zhenyun Du, Jian Yao, Pengfei Dou, Yuandong Zheng, Zhiming Wang, Xia Chen, Peipei Wang, Chungwah Ma, Hao Chen*, Xingxing Diao*, Kaiping Wang* & Kan Ding*.
Concurrent Evaluation of Liver and Kidney Function by NIR-II In Vivo Imaging to Assess the Efficacy of Flavonoids in Preventing Their Injuries.
Yuxin Bai, Ruihu Song, Zewei Zhang, Xiangmei Chen, Hao Chen*, and De-an Guo*.
2025
Dynamic Pathophysiological Insight into the Brain by NIR-II Imaging.
S. Chen#, Hao Chen# , X. Li, S. He, K. Shou, K. Qian, Z. Fang, F. Gu, B. Cang*, Z. Cheng*.
Salvianolic Acid B and Ginsenoside Rg1 Combination Attenuates Cerebral Edema Accompanying Glymphatic Modulation.
Lingxiao Zhang#, Yanan Shao#, Zhao Fang, Siqi Chen, Yixuan Wang, Han Sha, Yuhan Zhang, Linlin Wang, Yi Jin, Hao Chen* , Baohong Jiang*.
Development of a Dual-Modal PET/NIR-II Probe of Urofollitropin for Enhanced Follicle-Stimulating Hormone Receptor-Targeted Imaging in Diverse Tumors.
Yu Sun, Chunrong Qu, Kun Qian, Xiao Zhang, Jun Zhao*, Hao Chen* , and Zhen Cheng*.
Dual-Channel NIR-II Probe for Simultaneous Tracking of Nitric Oxide and Methylglyoxal in Inflammation: Enabling Rapid Drug Efficacy Assessment.
Mengzhen Cheng, Zhong He, Guannan Wang, Yang Yu, Ruihu Song, Ye Qin, Zhiming Wang*, Dean Guo*, and Hao Chen* .
Rapid discovery of drug-introduced multiple organ dysfunction via NIR-II fluorescent imaging.
Pu Jiang, Ruihu Song, Yue Hu, Xin He, Zewei Zhang, Xuemei Wei, Zhiming Wang*, De-an Guo*, Hao Chen* .
2024
Molecular Imaging of Ovarian Follicles and Tumors With Near-Infrared II Bioconjugates.
Y. Wang#, W. Lu#, Z. Chen#, Y. Xiao, Y. Wang, W. Gao, Z. Wang, R. Song, Z. Fang, W. Hu, X. Tong, K. Lee, Z. Pei, M. Xu, F. Zhang, H. Chen* , Y. Feng*.
Rimota-Gd: Paramagnetic Probe for In Vivo MRI Studies of the Cannabinoid 1 Receptor Distribution in the Mouse Brain.
Q. Ouyang#, F. Zhao#, J. Ye, M. Xu, S. Pu, W. Hui, X. Gao, X. Zha, Hao Chen, Z. Wang, F. Li, Z. Luo*, K. Wührich, G. Thompson*.
Design, synthesis and anticancer activity of β-carboline based pseudo-natural products by inhibiting AKT/mTOR signaling pathway.
L. Lv#, K. Song#, Y. Xiao#, J. Zheng, W. Zhang, L. Li, Y. Wei, Hao Chen, Y. He*, Z. Guo*, S. Nie*.
Radioactive ADME Demonstrates ARV-110's High Druggability Despite Low Oral Bioavailability.
Y. He#, Y. Zheng#, C. Zhu, P. Lei, J. Yu, C. Tang, H. Chen* , X. Diao*.
Systematic Structural Modification of Squaraine Dye for Near-Infrared Window One and Two Multiplexed In Vivo Imaging and Photothermal Therapy.
R. Song, Y. Dong, Z. Zhong, Q. Zhao, Y. Hu, M. Lei, P. Lei, Z. Jiang, K. Qian, C. Shi, Z. He, Y. Qin, J. Wang, and H. Chen* .
NIR-II fluorescence imaging without intended excitation light.
A. Ji#, H. Lou#, J. Li, Y. Hao, X. Wei, Y. Wu, W. Zhao*, H. Chen* , and Z. Cheng*.
Molecular Engineering of Bright NIR-I/NIR-II Nanofluorophores for High-Resolution Bioimaging and Tumor Detection in Vivo.
X. Zhou#, Y. Fan#, S. Li, K. Zhang, Y. Pei, Y. Zeng, X. Kang, L. Zhao, H. Chen , Y. Qin, W. Feng*, L. Liu*, Li Wu*.
2023
Clinically Translatable Solid-State Dye for NIR-II Imaging of Medical Devices.
D. Li#, H. Shi#, Q. Qi#, B. Chang#, Y. Jiang, K. Qian, X. Guan, P. Kang, N. Ma, Y. Zhang, Z. Zhang, X. Shi, C. Qu, Y. Wu, W. Chen, H. Chen , B. Li, L. Chen, Z. Li, S. Ma, L. Xu, Y. Zhang, J. Tian*, Z. Hu*, W. Jia*, Z. Cheng*.
Hypsochromic Shift Donor-Acceptor NIR-II Dye for High-Efficiency Tumor Imaging.
J. Li#, A. Ji#, M. Lei, L. Xuan, R. Song, X. Feng*, H. Lin*, and H. Chen* .
Rigid and Photostable Shortwave Infrared Dye Absorbing/Emitting beyond 1200 nm for High-Contrast Multiplexed Imaging.
R. Wei#, Y. Dong#, X. Wang, J. Li, Z. Lei, Z. Hu, J. Chen, H. Sun, H. Chen , X. Luo, X. Qian, and Youjun Yang*.
Development of a Novel 18F-abeled Probe for PET Imaging of Estrogen Receptor β-
Y. Zhou#, P. Lei#, J. Han, Z. Wang, A. Ji, Y. Wu, L. Zheng, X. Zhang, C. Qu, J. Min, W. Zhu, Z. Xu*, X. Liu*, H. Chen* , and Z. Cheng*.
Spectral and Biodistributional Engineering of Deep Near-Infrared Chromophore.
Y. Dong, X. Lu, Y. Li, W. Chen, L. Yin, J. Zhao, X. Hu, X. Li, Z. Lei, Y. Wu, H. Chen , X. Luo, X. Qian, and Youjun Yang*.
2022
Molecular Imaging of Matrix Metalloproteinase-2 in Atherosclerosis Using a Smart Multifunctional PET/MRI Nanoparticle.
Y. Tu, X. Ma, H. Chen , Y. Fan, L. Jiang, R. Zhang, Z. Cheng*.
Cell membrane-coated Mesoporous Silica Nanorods Overcome Sequential Drug Delivery Barriers against Colorectal Cancer.
J. Wang#, H. Pan#, J. Li, D. Nie, Y. Zhuo, Y. Lv, N. Wang, H. Chen , S. Guo, Y. Gan, X. Yang*, and M. Yu*.
Bioinspired Large Stokes Shift Small Molecular Dyes for Biomedical Fluorescence Imaging.
H. Chen# , L. Liu#, K. Qian, H. Liu, Z. Wang, F. Gao, C. Qu, W. Dai, D. Lin, K. Chen, H. Liu*, and Z. Cheng*.
Stable, Bright, and Long-Fluorescence-Lifetime Dyes for Deep-Near-Infrared Bioimaging.
J. Li#, Y. Dong#, R. Wei#, G. Jiang#, C. Yao, M. Lv, Y. Wu, S. H. Gardner, F. Zhang, M. Y. Lucero, J. Huang, H. Chen , G. Ge, J. Chan, J. Chen, H. Sun, X. Luo, X. Qian, and Youjun Yang*.
A Small-Molecule Based Organic Nanoparticle for Photothermal Therapy and Near-Infrared-IIb Imaging.
H. Lou, A. Ji, C. Qu, H. Liu, L. Jiang*, H. Chen* and Z. Cheng*.
Organic Single Molecule Based Nano-Platform for NIR-II Imaging and Chemo-Photothermal Synergistic Treatment of Tumor.
T. Chang, Q. Qiu, A. Ji, C. Qu*, H. Chen* and Z. Cheng*.
Acceptor Engineering for NIR-II Dyes with High Photochemical and Biomedical Performance.
A. Ji#, H. Lou#, C. Qu, W. Lu, Y. Hao, J. Li, Y. Wu, T. Chang, H. Chen* and Z. Cheng*.
A Novel NIR-II Nanoprobe for Precision Imaging of Micro-meter Sized Tumormetastases of Multi-organs and Skin Flap.
H. Lou, A. Ji, C. Qu, S. Duan, H. Liu, H. Chen* and Z. Cheng*.
Capillaries Segmentation of NIR-II Images and Its Application in Ischemic Stroke.
Y. Hao, A. Ji, R. Xing, W. Q. Zhu, B. Jiang, Y. Jian* and H. Chen* .
Liver Injury Long-term Monitoring and Fluorescent Image-guided Tumor Surgery Using Self-Assembly Amphiphilic Donor-acceptor NIR-II Dyes.
Q. Qiu, T. Chang, Y. Wu, C. Qu, H. Chen* and Z. Cheng*.
Development of Mitochondria-Targeted Small-Molecule Dyes for Myocardial PET and Fluorescence Bimodal Imaging.
L. Zheng#, Z. Wang#, X. Zhang, Y. Zhou, A. Ji, H. Lou, X. Liu*, H. Chen* and Z. Cheng*.
2021
Azide-dye unexpected bone targeting for near-infrared window II osteoporosis imaging.
X. Zhang#, A. Ji#, Z. Wang, H. Lou, J. Li, L. Zheng, Y. Zhou, C. Qu*, X. Liu*, H. Chen* and Z. Cheng*.
Smart Self-Assembly Amphiphilic Cyclopeptide-Dye for Near-Infrared Window-II Imaging.
H. Chen , K. Shou, S. Chen, C. Qu, Z. Wang, L. Jiang, M. Zhu, B. Ding, K. Qian, A. Ji, H. Lou, L. Tong, A. Hsu, Y. Wang, D. W. Felsher, Z. Hu*, J. Tian* and Z. Cheng*.
Differential Responses of Transplanted Stem Cells to Diseased Environment Unveiled by a Molecular NIR-II Cell Tracker.
H. Chen# , H. Yang#, C. Zhang, S. Chen, X. Zhao, M. Zhu, Z. Wang, Y. Wang, H. T. Wo, K. Li* and Z. Cheng*.
Improved functionality of Ligilactobacillus salivarius Li01 in alleviating colonic inflammation by layer-by-layer microencapsulation.
M. Yao, Y. Lu, T. Zhang, J. Xie, S. Han, S. Zhang, Y. Fei, Z. Ling, J. Wu, Y. Hu, S. Ji, H. Chen , B. Berglund, and L. Li*.
Engineering oxaliplatin prodrug nanoparticles for second near-infrared fluorescence imaging-guided immunotherapy of colorectal cancer.
Q. Zhu#, F. Sun#, T. Li, M. Zhou, J. Ye, A. Ji, H. Wang*, C. Ding*, H. Chen , Z. Xu* and H. Yu*.
Acceptor engineering of small-molecule fluorophores for NIR-II fluorescence and photoacoustic imaging.
Y. Li#, H. Zhou#, R. Bi, X. Li, M. Zha, Y. Yang, J. S. Ni, W. H. Liew, M. Olivo, K. Yao, J. Liu*, H. Chen* and K. Li*.
2020
First-in-class humanized FSH blocking antibody targets bone and fat.
S. Gera, D. Sant, S. Haider, F. Korkmaz, T. C. Kuo, M. Mathew, H. Perez-Pena, H. Xie, H. Chen , R. Batista, K. Ma, Z. Cheng, E. Hadelia, C. Robinson, A. Macdonald, S. Miyashita, A. Williams, G. Jebian, H. Miyashita, A. Gumerova, K. Ievleva, P. Smith, J. He, V. Ryu, V. DeMambro, M. A. Quinn, M. Meseck, S. M. Kim, T. R. Kumar, J. Iqbal, M. I. New*, D. Lizneva, C. J. Rosen, A. J. Hsueh, T. Yuen, and M. Zaidi*.
A thiopyrylium salt for PET/NIR-II tumor imaging and image-guided surgery.
X. Zhang#, B. Ding#, C. Qu, H. Li, Y. Sun, Y. Gai, H. Chen , H. Fang, K. Qian, Y. Zhang, Z. Cheng*, and X. Lan*.
Non-Invasive Photoacoustic Imaging of In Vivo Mice with Erythrocyte Derived Optical Nanoparticles to Detect CAD/MI.
Y. Liu, T. Hanley, H. Chen , S. R. Long, S. S. Gambhir, Z. Cheng, J. C. Wu, G. E. Fakhri, B. Anvari, and R. T. Zaman.
Semiconducting Polymer Nanoparticles as Theranostic System for Near-Infrared-II Fluorescence Imaging and Photothermal Therapy under Safe Laser Fluence.
Y. Yang#, X. Fan#, L. Li#, Y. Yang, A. Nuernisha, D. Xue, C. He, J. Qian*, Q. Hu*, H. Chen* , J. Liu*, and W. Huang.
Cancer cell membrane-coated rare earth doped nanoparticles for tumor surgery navigation in NIR-II imaging window.
X. Zhang#, S. He#, B. Ding, C. Qu, Q. Zhang, H. Chen , Y. Sun, H. Fang, Y. Long, R. Zhang*, X. Lan*, and Z. Cheng*.
Tuning the near infrared II emitting wavelength of small molecule dyes by single atom alteration.
K. Qian, C. Qu, X. Ma, H. Chen , M. Kandawa-Schulz, W. Song, W. Miao, Y. Wang*, and Z. Cheng*.
Mitochondria-targeted delocalized lipophilic cation complexed with human serum albumin for tumor cell imaging and treatment.
K. Qian, H. Chen , C. Qu, J. Qi, B. Du, T. Ko, Z. Xiang, M. Kandawa-Schulz, Y. Wang*, and Z. Cheng*.
2019
Hierarchically nanostructured hybrid platform for tumor delineation and image-guided surgery via NIR-II fluorescence and PET bimodal imaging.
Q. Zhang, H. Zhou, H. Chen , X. Zhang, S. He, L. Ma, C. Qu, W. Fang, Y. Han, D. Wang, Y. Huang, Y. Sun, Q. Fan, Y. Chen*, and Z. Cheng*.
Mitochondria-targeting fluorescent molecules for high efficiency cancer growth inhibition and imaging.
H. Chen# , J. Wang#, X. Feng, M. Zhu, S. Hoffmann, A. Hsu, K. Qian, D. Huang, F. Zhao, W. Liu, H. Zhang*, and Z. Cheng*.
A proof-of-concept application of water-soluble ytterbium (III) molecular probes in in vivo NIR-II whole body bioimaging.
Y. Ning#, S. Chen#, H. Chen , J. Wang, S. He, Y. Liu, Z. Cheng*, and J. Zhang*.
Quaternary ammonium salt based NIR-II probes for in vivo imaging.
C. Qu, Y. Xiao, H. Zhou, B. Ding, A. Li, J. Lin, X. Zeng, H. Chen , K. Qian, X. Zhang, W. Fang, J. Wu, Z. Deng, Z. Cheng*, and X. Hong*.
Controlled Nanobio Interface of Functional Nanoprobes for in Vivo Monitoring Enzyme Activity in Tumors.
Z. Sun, K. Cheng, Y. Yao, F. Wu, J. Fung, H. Chen , X. Ma, Y. Tu, L. Xing, L. Xia*, and Z. Cheng*.
Biodistribution, radiation dosimetry, and clinical application of a melanin-targeted PET probe, 18F-P3BZA, in patients.
X. Ma#, S. Wang#, S. Wang, D. Liu, X. Zhao, H. Chen , F. Kang, W. Yang, J. Wang*, and Z. Cheng*.
2018
Molecular targeted NIR-II probe for image-guided brain tumor surgery.
S. Kurbegovic, K. Juhl, H. Chen , C. Qu, B. Ding, J. Leth, K. Drzewiecki, A. Kjaer*, and Z. Cheng*.
Dual T1 and T2 weighted magnetic resonance imaging based on Gd3+ loaded bioinspired melanin dots.
L. Xu#, S. Hong#, Y. Sun, Z. Sun, K. Shou, K. Cheng, H. Chen , D. Huang, H. Xu*, and Z. Cheng*.
Pilot study of 64CuCl2 for PET imaging of inflammation.
L. Jiang, D. Song, H. Chen , A. Zhang, H. Wang*, and Z. Cheng*.
Epitope-specific monoclonal antibodies to FSHβ-increase bone mass.
Y. Ji#, P. Liu#, T. Yuen#, S. Haider, J. He, R. Romero, H. Chen , M. Bloch, S. Kim, D. Lizneva, L. Munshi, C. Zhou, P. Lu, J. Iqbal, Z. Cheng, M. New*, A. Hsueh, Z. Bian, C. Rosen, L. Sun, and M. Zaidi*.
Diketopyrrolopyrrole-based semiconducting polymer nanoparticles for in vivo second near-infrared window imaging and image-guided tumor surgery.
K. Shou#, Y. Tang#, H. Chen# , S. Chen, L. Zhang, A. Zhang, Q. Fan*, A. Yu*, and Z. Cheng*.
2017
Synthesis, characterization, and biomedical applications of a targeted dual-modal near-infrared-II fluorescence and photoacoustic imaging nanoprobe.
K. Cheng#, H. Chen# , C. Jenkins, G. Zhang, W. Zhao, Z. Zhang, F. Han, J. Fung, M. Yang, Y. Jiang, L. Xing*, and Z. Cheng*.
Multifunctional biomedical imaging in physiological and pathological conditions using a NIR-II probe.
K. Shou, C. Qu, Y. Sun, H. Chen , S. Chen, L. Zhang, H. Xu, X. Hong, A. Yu*, and Z. Cheng*.
Pilot study of 64Cu (I) for PET imaging of melanoma.
L. Jiang, Y. Tu, X. Hu, A. Bao, H. Chen , X. Ma, T. Doyle, H. Shi*, and Z. Cheng*.
A high quantum yield molecule-protein complex fluorophore for near-infrared II imaging.
A. Antaris#, H. Chen# , S. Diao, Z. Ma, Z. Zhang, S. Zhu, J. Wang, A. Lozano, Q. Fan, L. Chew, M. Zhu, K. Cheng, X. Hong*, H. Dai*, and Z. Cheng*.
Live imaging of follicle stimulating hormone receptors in gonads and bones using near infrared II fluorophore.
Y. Feng#, S. Zhu#, A. Antaris#, H. Chen , Y. Xiao, X. Lu, L. Jiang, S. Diao, K. Yu, Y. Wang, S. Herraiz, J. Yue, X. Hong, G. Hong, Z. Cheng*, H. Dai*, and A. Hsueh*.
2016
A small-molecule dye for NIR-II imaging.
A. Antaris#, H. Chen# , K. Cheng, Y. Sun, G. Hong, C. Qu, S. Diao, Z. Deng, X. Hu, B. Zhang, X. Zhang, O. Yaghi, Z. Alamparambil, X. Hong*, Z. Cheng*, and H. Dai*.
Novel benzo-bis (1, 2, 5-thiadiazole) fluorophores for in vivo NIR-II imaging of cancer.
Y. Sun#, C. Qu#, H. Chen , M. He, C. Tang, K. Shou, S. Hong, M. Yang, Y. Jiang, B. Ding, Y. Xiao, L. Xing, X. Hong*, and Z. Cheng*.
Dual-modal NIR-II fluorescence and photoacoustic imaging of thyroid carcinoma using EGFR-targeted donor-acceptor chromophore based nanoprobes.
K. Cheng, H. Chen , C. Jenkins, Z. Zhang, Z. Sun, J. Fung, X. Hong, L. Xing, and Z. Cheng.
2015
64Cu-labeled divalent cystine knot peptide for imaging carotid atherosclerotic plaques.
L. Jiang, Y. Tu, R. Kimura, F. Habte, H. Chen , K. Cheng, H. Shi, S. Sam Gambhir, and Z. Cheng*.
Total Synthesis of (±)-8-oxoerythrinine, (±)-8-oxoerythraline, and (±)livonine.
M. He#, C. Qu#, B. Ding, H. Chen , Y. Li, G. Qiu, X. Hu, and X. Hong*.
Strained cyclooctyne as a molecular platform for construction of multimodal imaging probes.
Y. Sun, X. Ma, K. Cheng, B. Wu, J. Duan, H. Chen , L. Bu, R. Zhang, X. Hu, Z. Deng, L. Xing, X. Hong*, and Z. Cheng*.
2013
Systematic research on the pretreatment of peptides for quantitative proteomics using a C18 microcolumn.
L. Zhai, C. Chang, N. Li*, D. Duong, H. Chen , Z. Deng, J. Yang, X. Hong*, Y. Zhu*, and P. Xu*.
HMDO-promoted peptide and protein synthesis in ionic liquids.
J. Duan, Y. Sun, H. Chen , G. Qiu, H. Zhou, T. Tang, Z. Deng, and X. Hong*.
2012
A simple and straightforward approach toward selective C=C bond reduction by hydrazine.
H. Chen , J. Wang, X. Hong, H. Zhou, and C. Dong*.
2011
Metal-free direct amidation of peptidyl thiol esters with α-amino acid esters.
H. Chen , M. He, Y. Wang, L. Zhai, Y. Cui, Y. Li, Y. Li, H. Zhou*, X. Hong*, and Z. Deng.